Micromotor-based dual aptassay for early cost-effective diagnosis of neonatal sepsis
Introduction (Article introduction authored by ICU Editorial Team) Improving the diagnosis of sepsis in newborns is crucial given their extended life expectancy, yet early detection remains challenging. A breakthrough has emerged with the development of a micromotor-based dual aptamer assay.…
Corticosteroids in Sepsis and Septic Shock: A Systematic Review, Pairwise, and Dose-Response Meta-Analysis
Introduction (Article introduction authored by ICU Editorial Team) The use of corticosteroids in managing sepsis and septic shock remains contentious despite extensive evaluation in randomized controlled trials (RCTs), systematic reviews, and meta-analyses. While some previous analyses suggest a potential decrease…
Clinical recommendations for the inpatient management of lower respiratory tract infections in children and adolescents with severe neurological impairment
Introduction (Article introduction authored by ICU Editorial Team) Children and adolescents facing severe neurological impairment (SNI) encounter complex medical challenges, often grappling with severe and recurrent lower respiratory tract infections (LRTIs). These infections, stemming from viruses and bacteria, present a…
Optimising the Treatment of Invasive Candidiasis – A Case for Combination Therapy
Introduction (Article introduction authored by ICU Editorial Team) Invasive candidiasis presents an escalating global health threat, characterized by increasing incidence and high mortality rates despite limited therapeutic choices. The rapid spread of antifungal resistance, especially among multidrug-resistant species, exacerbates this…