FORMULATION : CONTRACT RESEARCH & MANUFACTURING
More Reyra offers Contract Research & Manufacturing services specializing in fermentation and semi-synthesis products. The R&D facility is certified by DSIR (Department of Science & Industrial Research) and consists of three divisions:
R&D Fermentation
The facility includes capabilities for strain isolation, mutation, and passive selection of microbial strains; shake flask systems for strain improvement; laboratory fermenters; and a pilot plant for scaling up fermentation processes. Contract research and manufacturing services in fermentation are detailed below.
- Strain improvement program aimed at significantly boosting the titer of the target product and/or refining its impurity profiling.
- Media optimization: Utilization of cost-effective, locally sourced client media to enhance overall process productivity.
- Process development: Optimization of process control during scale-up for efficient high throughput that is also cost-effective.
- Process scale-up from shake flask to pilot and commercial scales.
- Development of optimized biotransformation processes.
- Continuous improvement of processes.
R&D has state of the art facility for extraction, isolation and purification of product from upstream (fermentation) process. The facility is having a scaled down version of all the major equipment at plant, thus giving high flexibility during process scale up. R&D facility is equipped with all essential equipment for complex organic synthesis chemistry. Some of the major equipment are various filtration units like Micro filtration, Ultra filtration and Nano filtration, Open column chromatography, and filtration systems.
Some of the major activities at Chemical R&D are:
- Development of Downstream process to support upstream process.
- Process optimization and scale up of processes from R&D to pilot and commercial.
- Continuous process improvement to improve the overall process yield and have a cost effective process.
The analytical laboratory conducts the following operations:
- Synthesis, isolation, and characterization of process impurities.
Competitive advantages of partnering with More Reyra as a CRAM provider:
- Expertise with diverse strains such as Actinomycetes, Streptomycetes, Bacteria, Fungi, E. coli, and various biocatalyst classes.
- Strong proficiency in manufacturing complex niche biotechnology products.
- Infrastructure capable of scaling processes from R&D through pilot to commercial stages.
- Research team led by senior scientists with Ph.D.s, microbiologists, and biotechnologists, offering extensive experience in biotechnology and downstream processes, ensuring timely project completion.
- Dedicated project teams.
- Robust R&D supported by analytical and regulatory expertise.
- Competitive pricing.
Our strengths in microbial fermentation, chromatographic purification, and semi-synthetic chemistry position us as the preferred partner for leading biopharmaceutical companies seeking CRAM (Contract Research & Manufacturing) opportunities in new fermentation and semi-synthetic NCEs/small molecules.